The efficacy and safety of aceclofenac-tizanidine fixed dose combination against aceclofenac along in patients with acute iow back pain was evaluted throught a double-blind, double-dummy, randomized, comparative, multicentric, parallelgroup study and it include 197 patients of either sex in the age range of 18-70 years with acute low back pain. The patients were randomized to receive either aceclofenac (100 mg)-tizanidine (2 mg) twice a day or aceclofenac (100 mg) alone twice a day for 7 days. The efficacy outcames measures include pain intensity, pain relife, functional imrairment, patients and investigoter globale efficacy assessment. Aceclofenac-tizanidine was significantly supeiror to acsclofenac for pain intensity (p>0.05) and pain relife, (p=0.00) on days 3 and 7. there was significant increase in spinal flexion in both the geoup feom bselime on days 3 and 7 with significant difference in favour of the combination geoup
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