The prophylaxis of surgical site infection (SS) winth antimicrobial drugs (postoperatively) has long been practiced. The type of antimimicrobial prophylaxis (AMp) and its manner of use in spinal surgery was investigated throught this study. The study included 1415 patients who underwent spinal surgery and the patients were classified into four groups according to the method of AMP administration-group 1, AMP was employed for 7 days, only postoperatively: group 2, initial AMP dosing was adiministered at the time of anesthesia induction, followed by administrstion of AMP for 5 days, including the day of the operation; group 3, initial AMP dosing was adiministered at the time of anesthesia induction, and AMP was adminitered for 3 days, including the day of the o0peration; group 4, the initial dosing was administered at the time of anesthesia induction, and AMP was administered for 2 days, including of the operation. The frequency of SSl was assessed in the four groups.
The frequencies of SSl in group 1-4 were 2.6%, 0.9%, 0% and 0%, respectively. Thus, the frequency of SSl decreased as the duration of the AMP administration period decreased. As a result of thorough implementation of preventive measures against peri0operative occurrence of infections, which include additional preoperative and introperative administration of AMP, the incidence of SSl could be decreased despite shortening the duration of AMP administration to 2 days.
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